许多报告已指出21三体的早期妊娠母血清AFP低于正常妊娠。在受累妊娠中,妊早期血清游离雌三醇(uE_3)水平较低,而hCG水平和hCG的α和β亚单位与正常妊娠无区别,于是从取CVS的妇女在孕早期测血清AFP和hCG以进一步评价二者能否做为非整倍体胎儿指标的实用性。对1478例于8～12孕周作CVS之前取母血清标本,所有病人发生胎儿非整倍体的危险率相当于大于或等于35岁的妇女。29例病人虽在CVS时为存 Many reports have pointed out that the trisomy 21 maternal serum AFP lower than normal pregnancy. In the first trimester of pregnancy, serum estradiol (uE_3) levels were lower during the first trimester of pregnancy and hCG levels and α and β subunits of hCG were not different from those of normal pregnancies, so women taking CVS measured serum AFP and hCG in early pregnancy To further evaluate whether the two can be used as aneuploidy fetus indicators of practicality. Maternal serum samples were taken from 1478 patients before CVS for 8-12 gestational weeks. All patients had a fetal aneuploidy equivalent to a 35-year-old female. 29 patients survived at CVS