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目的观察老年糖尿病患者应用格列美脲联合二甲双胍治疗的临床疗效。方法 90例老年糖尿病患者,随机分为对照组和研究组,各45例。对照组患者给予格列美脲治疗,研究组患者给予格列美脲联合二甲双胍治疗。比较两组患者血糖、血脂控制情况及不良反应发生情况。结果治疗后,研究组的空腹血糖(FPG)、餐后2小时血糖(2 h PG)以及糖化血红蛋白(Hb A1c)水平分别为(5.32±0.51)mmol/L、(8.21±1.03)mmol/L、(6.04±0.72)%,明显优于对照组的(6.85±1.02)mmol/L、(9.79±1.93)mmol/L、(7.86±1.25)%,差异具有统计学意义(P<0.05)。治疗后,研究组血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平均低于对照组,高密度脂蛋白胆固醇(HDL-C)水平高于对照组,差异具有统计学意义(P<0.05)。研究组不良反应发生率低于对照组,差异具有统计学意义(P<0.05)。结论对老年糖尿病患者实施格列美脲联合二甲双胍治疗,能够有效的控制患者血糖、血脂水平,减少不良反应的发生,提高治疗效果,具有临床推广意义。
Objective To observe the clinical efficacy of glimepiride combined with metformin in elderly patients with diabetes mellitus. Methods 90 cases of elderly diabetic patients were randomly divided into control group and study group, 45 cases each. Patients in the control group were treated with glimepiride, and patients in the study group were treated with glimepiride and metformin. Blood glucose, blood lipid control and adverse reactions were compared between the two groups. Results After treatment, fasting blood glucose (FPG), 2-hour postprandial blood glucose (2h PG) and Hb A1c were (5.32 ± 0.51) mmol / L and (8.21 ± 1.03) mmol / L (6.04 ± 0.72)%, which was significantly higher than that of the control group (6.85 ± 1.02) mmol / L, (9.79 ± 1.93) mmol / L and (7.86 ± 1.25)%, respectively. After treatment, the levels of serum total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) in the study group were lower than those in the control group, and the levels of high-density lipoprotein cholesterol (HDL- Group, the difference was statistically significant (P <0.05). The incidence of adverse reactions in the study group was lower than that in the control group, the difference was statistically significant (P <0.05). Conclusion Elderly patients with glimepiride combined with metformin treatment, can effectively control the blood sugar, blood lipid levels, reduce the incidence of adverse reactions and improve the therapeutic effect, with clinical significance.