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目的探讨新疆哈萨克族超重、肥胖学龄儿童血清超敏C-反应蛋白(hsCRP)、胰岛素抵抗指数(HOMA-IR)变化及临床意义。方法 2009年5月至2009年7月采用随机分层整群抽样的方法调查新疆伊犁哈萨克族自治州2475名6～14岁哈萨克族在校学生,对其中122例超重或肥胖儿童(超重、肥胖组)及119例年龄、性别相匹配的非肥胖儿童(对照组)分别测体重指数(BMI)、hsCRP、空腹血糖(FPG)、空腹胰岛素(FINS),计算HOMA-IR,比较两组差异及各指标的相关性。结果超重、肥胖组hsCRP、FINS、HMOA-IR明显高于对照组;FPG、低密度脂蛋白(LDL)、总胆固醇(CHO)、高密度脂蛋白(HDL)两组间差异无统计学意义。Pearson相关分析示,BMI与hsCRP、HMOA-IR、FINS有显著正相关趋势,与FPG有负相关趋势,但相关性无统计学意义(P>0.05)。与CHO、HDL、LDL有正相关趋势,但相关性无统计学意义(P>0.05)。多重线性回归显示,FINS、HMOA-IR、hsCRP、FPG、LDL均与BMI相关。结论新疆哈萨克族超重、肥胖儿童存在胰岛素抵抗,同时炎症因子CRP与新疆哈萨克族儿童超重、肥胖的发生及发展有密切关系。
Objective To investigate the changes of serum hs-CRP and HOMA-IR in overweight and obese school-aged children in Xinjiang and its clinical significance. Methods From May 2009 to July 2009, 2475 Kazakh students aged from 6 to 14 in Xinjiang Yili Kazakh Autonomous Prefecture were investigated by random stratified cluster sampling. Among 122 overweight or obese children (overweight and obesity group ) And 119 age-matched and non-obese children (control group) were measured for body mass index (BMI), hsCRP, fasting plasma glucose (FPG) and fasting insulin (FINS) Correlation of indicators. The results were overweight. The hsCRP, FINS and HMOA-IR in obese group were significantly higher than those in control group. There was no significant difference between the two groups in FPG, LDL, CHO and HDL. Pearson correlation analysis showed that there was a significant positive correlation between BMI and hsCRP, HMOA-IR and FINS and negative correlation with FPG, but the correlation was not statistically significant (P> 0.05). There was a positive correlation with CHO, HDL and LDL, but the correlation was not statistically significant (P> 0.05). Multiple linear regression showed that FINS, HMOA-IR, hsCRP, FPG and LDL were all associated with BMI. Conclusion Overweight and obese children in Xinjiang have insulin resistance. At the same time, the inflammatory factor CRP is closely related to the occurrence and development of overweight and obesity in Kazak children in Xinjiang.