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目的:了解硫酸吗啡控释片的镇痛效果,为临床合理用药提供依据。方法:采用开放式无对照法,对本院肿瘤科57例使用硫酸吗啡控释片治疗的晚期癌症病人镇痛效果进行系统监察,并进行分析。结果:吗啡控释片的日剂量范围在60～300 mg之间,大多病人均可获得良好的止痛效果,治疗后疼痛全部有所缓解,有效率为98.2%,不良反应为便秘、恶心、呕吐、头昏嗜睡、排尿困难,未见其他严重的药物不良反应。结论:硫酸吗啡控释片是癌痛病人可以长期使用、安全性高的重要止痛药物之一。
Objective: To understand the analgesic effect of morphine sulfate controlled-release tablets and provide the basis for clinical rational drug use. Methods: The open-label, non-controlled method was used to systematically monitor and analyze the analgesic effect of 57 patients with advanced cancer treated with morphine sulfate controlled release tablets in our hospital oncology department. Results: The daily dose of morphine controlled-release tablets ranged from 60 to 300 mg. Most patients received good analgesic effect. All the pain relief was relieved after treatment, with an effective rate of 98.2%. The adverse reactions were constipation, nausea and vomiting , Dizzy drowsiness, dysuria, no other serious adverse drug reactions. Conclusion: Morphine sulfate controlled-release tablets is one of the important analgesic drugs which can be used for a long time and has high safety.