对外用抗真菌新药联苯苄唑进行了急性毒性实验,结果证明小鼠灌胃的LD_(50)为6.5g/kg体重以上,皮下注射的LD_(50)大于20.0g/kg体重。给豚鼠、家兔正常或破损感染皮肤分别涂敷不同剂量、不同浓度的联苯苄唑制剂后均无明显刺激作用,病理组织学检查局部皮肤及全身各主要脏器均未见病理性损伤。正常人局部皮肤涂敷3％以下浓度的联苯苄唑制剂未出现红斑及自觉症状,表明联苯苄唑临床使用是安全的。 The acute toxicity test of bifonazole, a new antifungal agent, showed that the LD_ (50) of mice was above 6.5g / kg body weight and the LD 50 of subcutaneous injection was more than 20.0g / kg body weight. To guinea pigs, rabbits normal or damaged infected skin were coated with different doses of different concentrations of bifonazole preparations were no significant stimulating effect, histopathological examination of the local skin and the main organs of the body were no pathological lesions. Normal local skin application of 3% or less of the concentration of bifonazole preparations did not appear erythema and symptoms, indicating that the clinical use of bifonazole is safe.