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目的观察1,6-二磷酸果糖(FDP)治疗中重度新生儿缺氧缺血性脑病(HIE)的疗效。方法将60例新生HIE患儿随机分为2组;对照组30例给予常规治疗;治疗组30例,在常规治疗基础上尽早(生后6h内)应用FDP治疗。观察与比较两组意识恢复时间、吸吮能力、肌张力、原始反射恢复情况及行为神经评分测定。结果FDP治疗组意识恢复时间、吸吮能力、肌张力、原始反射恢复时间明显短于对照组。生后7d和14d的行为神经评分<35分者所占百分比,明显短于常规治疗组。结论FDP治疗中重度新生HIE疗效满意。
Objective To observe the efficacy of fructose-1,6-diphosphate (FDP) in the treatment of moderate-severe neonatal hypoxic-ischemic encephalopathy (HIE). Methods Sixty neonates with HIE were randomly divided into two groups. The control group was given routine treatment. Thirty patients in the treatment group were treated with FDP as early as possible (within 6 hours after birth) on the basis of routine treatment. The recovery time, sucking ability, muscle tone, recovery of primary reflex and behavioral neurological score of the two groups were observed and compared. Results The recovery time, sucking ability, muscle tone and recovery time of original reflex in FDP treatment group were significantly shorter than those in control group. The percentage of behavioral neurological score <35 at 7d and 14d after birth was significantly shorter than that of the conventional treatment group. Conclusion FDP treatment of moderate to severe neonatal HIE satisfactory results.