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目的了解网络成瘾障碍(internet addiction disorder,IAD)和品性障碍患儿事件相关电位的特点。方法应用美国Nicolet Bravo脑电生理仪,对37例IAD患儿、22例品行障碍患儿和30名正常儿童(对照组)进行失配性负波(MMN)和P300检测,分析比较3组之间MMN和P300的差异。结果与对照组相比,IAD组P300潜伏期延长[(346.0±21.1)ms vs(324.7±15.0)ms]、P300波幅增高[(3.1±1.8)μV vs(2.7±1.3)μV]、MMN潜伏期延长[(209.0±26.0)ms vs(190.0±22.0)ms]、MMN靶波波幅增高[(8.8±1.7)μV vs(5.2±2.1)μV];品行障碍组P300潜伏期延长[(341.7±14.4)ms vs(324.7±15.0)ms]、波幅增高[(4.7±2.1)μV vs(2.7±1.3)μV]、MMN潜伏期延长[(215.0±23.0)ms vs(190.0±22.0)ms],差异均具有统计学意义(P<0.01)。结论 IAD患儿和品行障碍患儿存在P300和MMN潜伏期延长,波幅升高,且IAD患儿延长较明显,MMN可作为P300检测的一种补充手段,而用于儿科临床。
Objective To understand the characteristics of event-related potentials in children with internet addiction disorder (IAD) and sexual dysfunction. Methods Nicolet Bravo electroencephalography was used to detect mismatch negative (MMN) and P300 in 37 children with IAD, 22 children with behavior disorder and 30 normal children (control group). The levels of Differences between MMN and P300. Results Compared with the control group, the P300 latency in IAD group was prolonged (346.0 ± 21.1 ms vs 324.7 ± 15.0 ms) and the amplitude of P300 was increased (3.1 ± 1.8 μV vs 2.7 ± 1.3 μV) (209.0 ± 26.0) ms vs (190.0 ± 22.0) ms], the MMN amplitude increased [(8.8 ± 1.7) μV vs (5.2 ± 2.1) μV]; P300 latency was prolonged in [341.7 ± 14.4] ms vs (324.7 ± 15.0) ms], amplitude ([4.7 ± 2.1] μV vs (2.7 ± 1.3) μV] and MMN latency [(215.0 ± 23.0) ms vs (190.0 ± 22.0) ms] Significance (P <0.01). Conclusions There is prolonged latency and amplitude of P300 and MMN in children with IAD and children with disabilities, and prolonged obviously in children with IAD. MMN can be used as a supplementary means to detect P300 in pediatric clinic.