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肾间质纤维化(renal interstitial fibrosis,RIF)是各种慢性肾病进展到终末期衰竭的共同归路,它是衡量慢性肾脏疾病病程进展的重要指标之一。纤维化最终的结局是大量细胞外基质(extracellular matrix,ECM)的沉积。调控ECM代谢的ECM降解酶类主要包括纤溶酶原激活物/纤溶酶原激活
Renal interstitial fibrosis (RIF) is the common path of all kinds of chronic kidney disease progression to end-stage failure. It is one of the important indicators to measure the progress of chronic kidney disease. The ultimate outcome of fibrosis is the deposition of a large extracellular matrix (ECM). ECM-degrading enzymes that regulate ECM metabolism mainly include plasminogen activator / plasminogen activator