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目的探讨人卵泡液诱导顶体反应(FOLLICULAR FLUID INDUCED ACROSOME REACTION,FFIAR)与人精子体外受精能力的关系。方法回顾性研究了783对夫妇完成的797个常规体外受精(IN-VITRO FERTILIZAITION,IVF)周期的结果,分析了FFIAR与IVF受精率等的关系。结果 IVF受精率与精子正常形态率极显著正相关(R=0．111, P<0．01),与精子密度略相关(R=0．086,P<0．05),与FFIAR的相关性没有统计学意义(R=0．052,P> 0．05)。回归分析结果表明,常规IVF受精率只与精子正常形态率显著正相关,与精子密度和FFIAR均没有相关性。FFIAR<2％组中,常规IVF受精率显著低于FFIAR≥2％组(60．5+29．3)％与(73．7+22．9)％,P<0．05;同时,FFIAR<2％的22个周期中,完全不受精的周期有2个(9．1％),其比例显著高于FFIAR≥2％的775个周期组(1％)。结论 FFIAR实验在IVF治疗过程中具有指导意义。当FFIAR<2％时,应当选择ICSI为授精方式,以降低卵子完全不受精的风险。
Objective To investigate the relationship between FOLLICULAR FLUID INDUCED ACROSOME REACTION (FFIAR) and in vitro fertilization ability of human sperm. Methods The results of 797 routine IVF cycles completed by 783 couples were retrospectively analyzed. The relationship between FFIAR and IVF fertility was also analyzed. Results There was a significant positive correlation between IVF fertilization rate and normal morphology of sperm (R = 0.111, P <0.01), but slightly correlated with sperm density (R = 0.086, P <0.05) Sex was not statistically significant (R = 0.052, P> 0.05). Regression analysis showed that the fertilization rate of routine IVF was only positively correlated with the normal morphology of sperm, but not with sperm density and FFIAR. In FFIAR <2% group, routine IVF fertilization rates were significantly lower than FFIAR≥2% (60.5 + 29.3)% and (73.7 + 22.9)%, P <0.05; meanwhile FFIAR Two out of 22 cycles with <2% complete fertilization (9.1%) were significantly more likely than 775 cycles (1%) with FFIAR ≥ 2%. Conclusion The FFIAR test is instructive in the treatment of IVF. When FFIAR <2%, ICSI should be chosen as insemination method to reduce the risk of egg being completely unfertilized.