已知雌激素和甲状腺素是刺激性激素结合球蛋白(SHBG)产生的主要激素。然而,尽管在正常月经周期中雌二醇(E_2)显著增加,而一些试验结果却未显示SHBG有何明显变化。本文试图用更敏感的结合测定法和放射免疫测定法(RIA)来进一步研究血清SHBG可能的周期性变化。12名21～33岁具有正常月经周期和生育史的妇女在一个月经周期中每日取血。另外4名妇女的年龄、身高、体重与正常月经周期妇女相似,但至少闭经4个月, Estrogen and thyroxine are known to be the major hormones produced by the stimulating hormone-binding globulin (SHBG). However, although there is a significant increase in estradiol (E 2) during the normal menstrual cycle, some trials did not show any significant change in SHBG. This article attempts to further investigate the possible cyclical changes in serum SHBG using more sensitive binding assays and radioimmunoassays (RIA). Twelve women aged 21-33 years with normal menstrual cycles and fertility were bled daily for one menstrual cycle. The other four women were similar in age, height and weight to women in the normal menstrual cycle but had at least amenorrhea for 4 months,