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近20多年来,克罗米酚一直用于诱导不孕症妇女的排卵。排卵率高达70～90％。但妊娠率却只有排卵率的一半,妊娠率低,可能与克罗米酚在宫颈粘膜和子宫内膜上的抗雌激素作用有关。一部分不孕症妇女,在应用克罗米酚后,体内雌激素水平升高,这一反应可能同她们无排卵性失调的性质有关。因此我们决定对下丘脑性无排卵和多囊卵巢患者血清雄激素水平进行研究,同时观察卵泡发育的情况,血清促卵泡激素,黄体生成素,雌二醇和黄体酮的变化。
Clomiphene has been used to induce ovulation in infertile women for more than 20 years. Ovulation rate up to 70 ~ 90%. However, the pregnancy rate is only half of the ovulation rate, low pregnancy rate, which may be related to the anti-estrogen effect of clomiphene on the cervical mucosa and endometrium. Some infertile women, estrogen levels after the application of clomiphene, the response may be related to their nature of anovulatory disorders. Therefore, we decided to study the serum androgen levels of hypothalamic anovulatory and polycystic ovary patients, and observe the changes of follicular development, serum follicle-stimulating hormone, luteinizing hormone, estradiol and progesterone.