作者报道了一家三代6例患有甲亢的女性患者,年龄自12～80岁。5例具有临床和实验室特征,仅1例12岁的女孩缺乏甲亢症状,有甲状腺轻度肿大及实验室各项甲状腺功能的异常。年龄愈大临床表现愈明显。她们的促甲状腺激素(TSH)增高,经视野、蝶鞍平片及多个角度切层、计算机切层检查排除了垂体瘤。TSH的分泌是非自主性的,每天用单剂量的三碘甲状腺氨 The authors reported a three generation 6 female patients with hyperthyroidism, aged from 12 to 80 years old. Five patients had clinical and laboratory characteristics. Only one 12-year-old girl lacked symptoms of hyperthyroidism, mild thyroid enlargement and abnormal thyroid function in the laboratory. The older the more obvious clinical manifestations. Their thyroid stimulating hormone (TSH) increased by visual field, sella flat sheet and multiple angle layer, computer tomography ruled out pituitary tumor. TSH secretion is involuntary, with a single dose of triiodothyronine daily