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目的:高原训练引起的运动性疲劳机制和如何恢复体力已成为高原医学研究的重点。富氧水对高原人体自由基代谢和血乳酸的影响是其中需验证的问题。方法:实验于2006-05/08在海拔3700m、5200m和5380m高原现场进行。①对象:选择海拔3700m、已习服半年的男性士兵10名,年龄18～20岁;海拔5380m、已习服2个月的男性士兵10名,年龄18～21岁;首次进驻海拔5200m的男性青年36名,年龄18～24岁,均分为实验组和对照组。以上受试者上高原前体检确认健康,均自愿参加试验。②实验过程:以5%葡萄糖注射液250mL为基液,选用氧流量为3L/min,溶氧时间为8min,制成氧分压80～95kPa的富氧水。对海拔3700m和海拔5380m受试者进行2次负荷运动,2次运动中间间隔1周口服富氧水2次/d,500mL/次,连服3d。对首次进驻海拔5200m的受试者,到达海拔3700m时,实验组口服富氧水,对照组口服5%葡萄糖注射液,均500mL/次,2次/d,连服3d,到达海拔5200m,再连服富氧水5d,共服9d。③评估:于第1次负荷运动后(服富氧水前)、第2次运动后、实验组和对照组服富氧水/5%葡萄糖注射液9d后检测血超氧化物歧化酶、丙二醛、血乳酸和尿素氮水平。结果:①海拔3700m和5380m负荷运动,口服富氧水后较口服富氧水前超氧化物歧化酶增高(P<0.01);丙二醛、血乳酸、尿素氮降低(P<0.01或0.05)。②首次进驻海拔5200m,实验组较对照组超氧化物歧化酶增高(P<0.05);丙二醛、血乳酸降低(P<0.01);尿素氮差异无统计学意义(P>0.05)。结论:实验结果验证富氧水可增加组织对氧的利用,具有增强人体耐缺氧、抗疲劳的作用。
Objective: The mechanism of exercise-induced fatigue caused by altitude training and how to restore physical strength have become the focus of high altitude medical research. The effect of oxygen-enriched water on free radical metabolism and blood lactate in the plateau is one of the problems to be verified. Methods: The experiment was conducted at the site of 3700m above sea level, 5200m and 5380m highlands on May 18, 2006. ① Subjects: 10 male soldiers aged 18 to 20 years old who had served for half a year at an altitude of 3700m; 10 male soldiers who had served for 2 months at an elevation of 5380m; aged 18 to 21 years old; men stationed at an elevation of 5200m for the first time 36 young people, aged 18 to 24 years old, were divided into experimental group and control group. The above subjects on the plateau physical examination to confirm the health, are willing to participate in the experiment. ②Experimental process: 250mL of 5% glucose injection was used as the base liquid, oxygen flow rate was 3L / min and dissolved oxygen time was 8min, oxygen-enriched water with oxygen partial pressure of 80 ~ 95kPa was made. Subjects with an altitude of 3700m and an elevation of 5380m were subjected to two load exercises. Oxygen-enriched water was orally administered twice a day for 2 weeks at a time interval of 500mL once a day for three consecutive days. For the first time stationed at 5200m above sea level, at the altitude of 3700m, the experimental group orally administered oxygen-enriched water and the control group received 5% dextrose injection, each at 500mL / time, twice daily for 3 days and reached an altitude of 5200m Even serving oxygen-rich water 5d, a total of service 9d. ③ assessment: after the first load exercise (before serving oxygen-rich water), the second exercise, the experimental group and the control group served oxygen-rich water / 5% glucose injection 9d after the detection of serum superoxide dismutase, C Dialdehyde, blood lactate and urea nitrogen levels. Results: (1) The activities of superoxide dismutase (SOD) were significantly increased at 3700 m and 5380 m altitude after oral administration of oxygen-enriched water (P <0.01 or 0.05) . (2) The first stationed at an altitude of 5200m, the experimental group compared with the control group superoxide dismutase increased (P <0.05); malondialdehyde, blood lactate decreased (P <0.01); urea nitrogen difference was not statistically significant (P> 0.05). Conclusion: The experimental results verify that oxygen-enriched water can increase the utilization of oxygen by tissues and enhance the body’s resistance to hypoxia and fatigue.