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目的:探讨沐舒坦支气管肺泡灌洗对胎粪吸入新生儿的疗效观察及其对血氧的影响。方法:将入住NICU行机械通气的胎粪吸入新生儿60例随机分为两组,即沐舒坦支气管肺泡灌洗组(治疗组)和生理盐水灌洗组(对照组),每组30例,治疗组每次应用沐舒坦1.5mg加入生理盐水1ml/h支气管肺泡灌洗,对照组单用生理盐水1ml/h支气管肺泡灌洗,比较两组患者在支气管肺泡灌洗前、灌洗10次后的血氧值,主要数值如PaO2,PaCO2的变化。结果:试验组与对照组相比,气道灌洗前血氧值无明显差异,灌洗10次后的差异显著。结论:沐舒坦支气管肺泡灌洗能改善胎粪吸入新生儿机械通气时的通气效率。
Objective: To investigate the curative effect of mucosolvan bronchoalveolar lavage on neonates with meconium aspiration and its effect on blood oxygen. Methods: Sixty cases of neonatal meconium admitted to NICU undergoing mechanical ventilation were randomly divided into two groups: control group, ambroxol bronchoalveolar lavage group (treated group) and saline lavage group (control group) In the treatment group, mucosolvan 1.5mg was added into 1ml / h bronchoalveolar lavage of normal saline and the control group was treated with bronchoalveolar lavage of 1ml / h saline alone. Before the bronchoalveolar lavage, Blood oxygen values, the main values such as PaO2, PaCO2 changes. Results: Compared with the control group, there was no significant difference in the blood oxygen value before airway lavage. After lavage for 10 times, the difference was significant. Conclusions: Mucosolvan bronchoalveolar lavage can improve ventilation efficiency of meconium aspiration in neonatal mechanical ventilation.