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为研究免疫因素对男性不育的影响，用免疫组化方法对睾丸性无精子症的睾丸活检标本进行免疫病理观察；用明胶凝集试验测定少精子症和精子活动力低下者精浆中的抗精子抗体。结果表明：（１）无精子症睾丸标本６７例，其中ＩｇＧ、ＩｇＡ阳性２７例，ＩｇＭ阳性２４例，分别沉积于生精小管基底膜、生精细胞和间质血管壁；（２）少精子症和精子活动力低下的４０例精浆中抗精子抗体阳性者１１例。提示男性不育中有２种免疫作用机制：（１）免疫球蛋白沉积于生精小管壁基底膜，间质血管壁和生精细胞，直接影响睾丸的生精功能；（２）抗精子抗体直接作用于精子，影响精子的受精功能。
In order to study the influence of immune factors on male infertility, immunohistochemistry was used to detect the testicular biopsy specimens of testicular azoospermia. The gelatin agglutination test was used to determine the serum levels of oligozoospermia and sperm motility in seminal plasma Sperm antibodies. The results showed that: (1) There were 67 cases of testicular azoospermia, of which 27 cases were positive for IgG and IgA and 24 cases were positive for IgM, which were deposited on the basement membrane, spermatogenic cells and interstitial blood vessel wall respectively. (2) Symptoms and sperm motility in 40 cases of seminal plasma anti-sperm antibody positive in 11 cases. Prompt male infertility in 2 kinds of immune mechanism: (1) immunoglobulin deposition in the basement membrane of the seminiferous tubules, interstitial blood vessel wall and spermatogenic cells, directly affect the testis spermatogenesis; (2) anti-sperm Antibodies directly affect the sperm, affecting the fertilization function of sperm.