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中缝核5-羟色胺能神经元通过其广泛的神经投射影响大脑多方面的功能,包括抑郁和焦虑、睡眠-觉醒周期、奖赏、决策中的耐心以及性别取向等.背侧中缝核和中央中缝核的5-羟色胺能神经元对嗅球有密集的神经投射,从而调控嗅觉信息的初步表征和编码.近年来,随着电生理、光学成像及光遗传技术的应用,关于中缝核5-羟色胺能神经元对嗅球的调制作用研究不断出现,大量离体和在体实验证据表明中缝核5-羟色胺能神经元对嗅球及嗅觉相关行为有广泛的调制.本文从嗅球不同神经元类型角度,就中缝核5-羟色胺能神经投射对嗅球的调控作用及其神经机制研究进展进行了总结.
Mesenteric serotonergic neurons affect a wide range of brain functions through a wide range of neuronal projections, including depression and anxiety, sleep-wake cycles, rewards, patient decision-making and gender orientation, etc. Dorsal and meso-nucleus Serotonergic neurons have a dense neuronal projection on the olfactory bulb to regulate the initial characterization and coding of olfactory information.In recent years, along with the application of electrophysiology, optical imaging and optogenetic technology, There are many studies on the modulation of the olfactory bulb by the metamorphosis, a large number of experimental evidence in vitro and in vivo show that there is a wide range of modulation of the olfactory bulb and olfactory related activity of the serratoid serotonergic neurons.From the perspective of different types of neurons in the olfactory bulb, The effects of serotonergic projection on the regulation of olfactory bulb and its neural mechanism are summarized.