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目的 :观察新生儿缺氧缺血性脑病 (HIE)时血清肿瘤坏死因子 (TNF)水平的变化。方法 :用放射免疫的方法检测 15例足月正常新生儿及 2 5例足月HIE新生儿在生后 2 4h内、第 3天和第 7～ 10天血清TNF水平。结果 :HIE新生儿在生后 3天内血清TNF水平显著高于正常新生儿 ,第 7～ 10天与正常对照组无显著差异。结论 :TNF参与了新生儿HIE的病理生理过程。
Objective: To observe the changes of serum tumor necrosis factor (TNF) in neonates with hypoxic-ischemic encephalopathy (HIE). Methods: The levels of serum TNF were measured by radioimmunoassay in 15 normal newborn infants and 25 full term HIE neonates within 24 hours, 3 days and 7 to 10 days after birth. Results: The levels of serum TNF in HIE neonates were significantly higher than those in normal neonates within 3 days after birth. There was no significant difference between the 7th and 10th days in normal neonates. Conclusion: TNF is involved in the pathophysiological process of neonatal HIE.