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目的:观察知母宁对慢性低O2高CO2肺心病大鼠心肌及肝脏组织超氧化物歧化酶(superox-ide dismutase,SOD)、丙二醛(malondialdehyde,MDA)的影响。方法:将SD大鼠分为正常对照组、4周低O2高CO2组(模型组)、4周低O2高CO2+知母宁组(知母宁组);制备慢性低O2高CO2肺心病大鼠模型,观察各组心肌、肝组织病理学改变;测定心肌、肝组织超氧化物歧化酶(SOD)、丙二醛(MDA)的含量。结果:光镜下模型组大鼠心肌损伤、肝组织脂肪变性明显,知母宁组上述改变不明显;模型组大鼠肝组织MDA较正常组显著升高,而SOD显著下降,知母宁组大鼠肝组织MDA较模型组显著降低,而SOD显著升高;模型组大鼠心肌组织MDA较正常组显著升高,而SOD显著下降,知母宁组大鼠心肌组织MDA较模型组显著降低,而SOD显著升高。结论:慢性低O2高CO2肺动脉高压状态下大鼠心肌、肝脏组织脂质过氧化增加,知母宁能减轻慢性低O2高CO2大鼠心肌、肝脏组织脂质过氧化作用。
Objective: To observe the effects of Zhuningning on superoxide dismutase (SOD) and malondialdehyde (MDA) in myocardium and liver of chronic hypoxic hypercapnic pulmonary heart disease (COPD). Methods: SD rats were divided into normal control group, 4-week hypoxia-CO2 group (model group), 4-week hypoxia-CO2 + Zhimuening group The changes of myocardial and liver pathology in each group were observed. The contents of superoxide dismutase (SOD) and malondialdehyde (MDA) in myocardium and liver were measured. Results: Myocardial injury and hepatic steatosis were obvious in the model group under light photon microscope, while the changes in the Zhuningning group were not obvious. The content of MDA in the model group was significantly higher than that in the normal group and SOD was significantly decreased Compared with the model group, the MDA in the liver of the rats in the Zhuningning group was significantly lower than that in the untreated group, while the SOD level was significantly increased. The content of MDA in the model group was significantly higher than that in the normal group , While SOD increased significantly. CONCLUSION: Lipid peroxidation in myocardium and liver of rats with chronic hypoxia and hypercapnia in pulmonary arterial hypertension is increased. Zhiminning can attenuate lipid peroxidation in myocardium and liver of chronic hypoxic hypercapnia rats.