论文部分内容阅读
约有80%的垂体性柯兴氏病患者,由于垂体促肾上腺皮质激素分泌过多,有双侧肾上腺皮质增生,并常伴有小垂体肿瘤。少数病人有自主性分泌氢可的松(皮质醇)的肾上腺腺瘤或癌肿,或由于产生异位促肾上腺皮质激素的肿瘤引起如支气管癌或胰腺的类癌,病人的血浆促肾上腺皮质激素(ACTH)浓度正常或升高,并对甲吡酮呈阳性反应,17酮类固醇也增高。肾上腺肿瘤引起的柯兴氏综合征,由于反馈抑制,血浆ACTH常不能检出,对甲吡酮刺激反应缺如或减弱。在异位ACTH综合征中,血浆ACTH浓度
About 80% of Pituitary Cushing’s patients, due to excessive secretion of adrenocorticotropic hormone, bilateral adrenal hyperplasia, and often accompanied by small pituitary tumors. A minority of patients have adrenal adenoma or cancer secreting hydrocortisone (cortisol) autonomously, or carcinoids such as bronchus or pancreas due to ectopic adrenocorticotrophic tumors, the patient’s plasma adrenocorticotropic hormone (ACTH) normal or elevated concentrations, and positive for metyrapone, 17 ketosteroids also increased. Cushing’s syndrome caused by adrenal tumors, due to feedback inhibition, plasma ACTH can often be detected, the lack or decrease of the response to metyrapone. In ectopic ACTH syndrome, plasma ACTH concentrations