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人体皮肤渗透性的部位差异报道较多,但很少有人研究人体特定部位皮肤渗透性的变异。本文采用离体皮肤静态渗透和限量渗透技术,根据不同化合物对离体皮肤渗透性测量参人体皮肤渗透性的部位差异报道较多,但很少有人研究人体特定部位皮肤渗透性的变异。本文采用离体皮肤静态渗透和限量渗透技术,根据不同化合物对离体皮肤渗透性测量参数(渗透量、渗透率、延搁时间、最大渗透率及48小时渗透百分量)的变异系数,评价人体腹部皮肤渗透性的样本内变异(intra-SV)~(*1)及样本间变异(inter-SV)~(*2)。并确定了离体皮肤
There are many reports on the site differences of human skin permeability, but few people study the skin permeability variation in a specific part of the human body. In this paper, static and limited osmotic skin exfoliation techniques were used. According to the different skin permeability of different compounds, the differences in the permeability of the human skin were reported. However, few studies have investigated the skin permeability variation in specific parts of the human body. In this paper, static skin permeability and limited osmotic techniques were used to evaluate the abdomen of human body according to the coefficients of variation of different skin permeability parameters (permeation, permeability, delay time, maximum permeability and 48-hour osmotic percentage) Intra-SV (~ 1) and inter-SV (~ 2) of skin permeability were observed. And determine the skin in vitro