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目的研究在妊娠合并甲状腺功能减退症患者中采取L-T4替代治疗的临床效果。方法选取我院自2015年10月~2016年10月期间收治的52例妊娠合并甲状腺功能减退症患者,采取随机数字表法形式随机分为两组,为参照组(n=26)与实验组(n=26),参照组患者实行我院常规治疗,实验组患者实行左旋甲状腺素(L-T4)替代治疗,分析对比两组患者经不同治疗后并发症发生情况、妊娠结局以及TSH、FT4、FT3等甲状腺激素变化情况。结果实验组患者TSH(4.18±0.21)、FT4(14.28±0.54)、FT3(3.58±0.12)等指标均显著优于参照组患者TSH(5.98±0.34)、FT4(9.98±0.44)、FT3(2.56±0.32),P<0.05,差异具有统计学意义;实验组并发症发生情况、妊娠结局等等指标显著优于参照组,组间差异显著且P<0.05,具有统计学意义。结论将左旋甲状腺素(L-T4)替代治疗应用在妊娠合并甲状腺功能减退症患者中存在确切疗效,可以有效控制甲状腺功能减退症产妇的病情,改善母婴结局以及预后,具有广泛的临床应用价值。
Objective To study the clinical effect of L-T4 replacement therapy in pregnant women with hypothyroidism. Methods Fifty-two patients with pregnancy-induced hypothyroidism admitted to our hospital from October 2015 to October 2016 were randomly divided into two groups (n = 26) and random numbers table (n = 26) (n = 26). The patients in the reference group were treated routinely in our hospital. The patients in the experimental group were treated with L-T4 replacement therapy. The complication, pregnancy outcome, TSH, FT4 , FT3 and other thyroid hormone changes. Results The indexes of TSH (4.18 ± 0.21), FT4 (14.28 ± 0.54) and FT3 (3.58 ± 0.12) in the experimental group were significantly better than those in the reference group (5.98 ± 0.34, FT4, FT3, ± 0.32), P <0.05, the difference was statistically significant. The incidence of complications and pregnancy outcome in the experimental group were significantly better than those in the reference group. There was significant difference between the two groups (P <0.05), with statistical significance. Conclusion The application of L-T4 replacement therapy in pregnant women with hypothyroidism has the exact effect, which can effectively control the condition of hypothyroidism maternal, improve maternal and infant outcomes and prognosis, and has a wide range of clinical value .