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目的探讨核因子κB(NF-κB)与胰腺癌肿瘤血管新生的作用以及临床意义。方法对40例胰腺癌的石蜡包埋标本作NF-κB、CD31免疫组织化学染色,镜下对NF-κB评分和CD31标记的肿瘤微血管密度(MVD)计数。结果NF-κB染色评分高的胰腺癌MVD明显增加(P<0.01)。肿瘤直径>3.0cm组NF-κB染色评分明显高于<3.0cm组(P<0.01);出现脉管癌栓、转移及TNMⅢ期者的NF-κB染色评分高(P<0.05)。术后生存期>1年与<1年者NF-κB评分无明显差异(P>0.05)。结论NF-κB与胰腺癌的肿瘤血管新生可能具有某些相关性。NF-κB有可能成为胰腺癌分化、浸润、转移分析的指标之一。
Objective To investigate the role of nuclear factor κB (NF-κB) in angiogenesis of pancreatic cancer and its clinical significance. Methods 40 cases of pancreatic cancer were paraffin embedded specimens for NF-κB, CD31 immunohistochemical staining, NF-κB score and CD31 labeled tumor microvessel density (MVD) count. Results MVD in pancreatic cancer with high NF-κB staining was significantly increased (P <0.01). The NF-κB staining score of tumor diameter> 3.0cm group was significantly higher than that of <3.0cm group (P <0.01). The NF-κB staining score of tumor embolus, metastasis and TNMⅢwere high (P <0.05). There was no significant difference in NF-κB score between postoperative survival> 1 year and <1 year (P> 0.05). Conclusion NF-κB may have some correlation with tumor angiogenesis in pancreatic cancer. NF-κB may become one of the indicators of pancreatic cancer differentiation, invasion and metastasis.