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目的:观察冠状动脉内注射硝普钠对冠状动脉慢血流(CSF)的影响,为临床治疗CSF提供新方法。方法:将2010年1月至2010年12月,在我院心脏内科住院,伴有胸痛症状,经冠脉造影(CAG)诊断为CSF的患者12例,经患者知情同意后,通过冠状动脉造影导管向冠状动脉内注射硝普钠200～400μg后,3～5分钟内观察冠状动脉血流速度的改善情况,对比冠状动脉内注射硝普钠前后冠状动脉血流帧计数,根据CTFC帧计数,评估冠状动脉内注射硝普钠对冠状动脉血流速度的影响。结果:冠状动脉内注射硝普钠200～400μg后患者冠脉血流速度明显改善,冠状动脉血流帧计数较治疗前明显降低,差异有统计学意义(P<0.05),治疗改善率达83.3%,且患者治疗过程中无低血压等不良反应发生。结论:冠状动脉注射硝普钠可安全、有效地改善CSF患者冠状动脉慢血流现象。
Objective: To observe the effect of intracoronary injection of sodium nitroprusside on slow blood flow of coronary artery (CSF), and to provide a new method for clinical treatment of CSF. Methods: From January 2010 to December 2010, 12 patients were hospitalized in the department of cardiology of our hospital, with symptoms of chest pain and diagnosed with CSF by coronary angiography (CAG). After informed consent of the patients, coronary angiography Catheter injection of sodium nitroprusside into the coronary artery 200 ~ 400μg, within 3 to 5 minutes to observe the improvement of coronary blood flow velocity, compared with intracoronary injection of sodium nitroprusside before and after coronary blood flow frame count, according to CTFC frame count, To evaluate the effect of intracoronary injection of sodium nitroprusside on coronary blood flow velocity. Results: Coronary blood flow velocity was significantly improved after intracoronary injection of sodium nitroprusside (200-400 μg). The coronary blood flow frame count was significantly lower than that before treatment (P <0.05), and the improvement rate was 83.3 %, And no adverse reactions such as hypotension during the treatment of patients. Conclusion: Coronary injection of sodium nitroprusside can safely and effectively improve the slow coronary flow in patients with CSF.