1981～1989年在美国费城及市郊对健康儿童进行了10次Oka/Merck水痘疫苗试验,儿童接种时的年龄为12月龄～17岁。对所有接种后6周以上出现水痘样皮疹的儿童进行了检查。结果在2163名接种者中有164名怀疑为水痘者接受了检查,其中114例诊断为水痘。对其中52例患儿进行血清学检测,证明是水痘—带状疱疹病毒感染。水痘出现时间为免疫后2～96个月。临床症状包括:瘙痒39％;发热9％;头痛7％;淋巴结病3％;不适2％,54％的患儿除皮疹外无其他 From 1981 to 1989, 10 Oka / Merck chickenpox vaccine tests were conducted on healthy children in Philadelphia and the suburbs of the United States. The vaccination age ranged from 12 months to 17 years. All children with a chickenpox-like rash over 6 weeks after vaccination were examined. Results Of the 2163 vaccinates, 164 were suspected of having chickenpox and 114 were diagnosed with chickenpox. Serological tests were performed on 52 of these children, proving a varicella-zoster virus infection. Chickenpox occurs after 2 to 96 months after immunization. Clinical symptoms include: pruritus 39%; fever 9%; headache 7%; lymphadenopathy 3%; discomfort 2%, 54% of children with no other than skin rashes