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年龄超过65岁的老年人,慢性疾病的发病率不断升高,药物治疗目的是为了维持病人的正常功能和提高生命质量。由于老年人机体生理功能发生了一些变化,从而导致了药物动力学,药效学的改变。 老年人药物动力学特点 吸收和生物利用度:老年人最明显的生理变化是消化系统。在口腔内,包括牙齿的减少和唾液分泌的降低,导致了咀嚼的困难。口腔干燥是诱导药物副作用的原因之一。另外,老年人胃肠道蠕动和胃排空率降低,使药物的运输延缓,易引
Older persons over the age of 65, the incidence of chronic diseases continues to rise, the purpose of drug treatment is to maintain the normal function of patients and improve the quality of life. Due to some changes in the physiological functions of the elderly, leading to changes in pharmacokinetics, pharmacodynamics. Pharmacokinetics of the Elderly Features Absorption and Bioavailability: The most obvious physiological change in the elderly is the digestive system. In the mouth, including the reduction of teeth and salivary secretion, resulting in the difficulty of chewing. Oral dryness is one of the causes of drug side effects. In addition, the elderly gastrointestinal motility and gastric emptying decreased, so that drug delivery delay, easy to lead