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目的检测煤工尘肺模型大鼠学习记忆能力的改变,并对其相关机制进行初步探讨。方法 Morris水迷宫评价煤工尘肺模型大鼠的学习和记忆能力,检测煤工尘肺模型大鼠脑组织内丙二醛(MDA)含量,超氧化物歧化酶(SOD)活性。结果与对照组相较煤工尘肺模型组大鼠逃避潜伏期明显延长(P<0.01);煤工尘肺模型大鼠脑内MDA含量(2.08±0.72)nmol/mgprot显著高于对照组(0.69±0.28)nmol/mgprot(P<0.05);SOD活性(64.56±16.07)U/mgprot明显低于对照组(89.01±12.74)U/mgprot(P<0.05)。结论煤工尘肺模型大鼠学习记忆能力下降,可能与脑组织中MDA含量升高和SOD活性降低有关。
Objective To detect the change of learning and memory abilities in coal worker’s pneumoconiosis model rats and to explore the related mechanism. Methods The Morris water maze was used to evaluate the learning and memory abilities of coal workers ’pneumoconiosis model rats. The levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in the brain tissue of coal workers’ pneumoconiosis model were detected. Results Compared with the control group, the escape latency of rats in model group was significantly longer (P <0.01). The content of MDA in brain of model workers with pneumoconiosis (2.08 ± 0.72) nmol / mgprot was significantly higher than that in control group (0.69 ± 0.28 ) nmol / mgprot (P <0.05). The SOD activity (64.56 ± 16.07) U / mgprot was significantly lower than that of the control group (89.01 ± 12.74) U / mgprot (P <0.05). Conclusion The decreased ability of learning and memory in coal worker’s pneumoconiosis model rats may be related to the increase of MDA content and the decrease of SOD activity in brain tissues.