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目的对蛇床子素微乳的制备以及透皮能力进行分析探讨。方法经蛇床子素在不同乳化剂、助乳化剂以及油相中的溶解度对空白微乳处方进行设计,并对所制备的微乳黏度、粒径及电导率进行考察,利用药物渗透仪对蛇床子素微乳的透皮速率进行测定,同蛇床子素凝胶进行对比。结果所制备的蛇床子微乳素的黏度为8.05mPas,粒径为57.9nm,电导率为122μscm-1。经对比得知蛇床子素微乳透皮速率较蛇床子素凝胶大(P<0.05)。结论蛇床子素微乳的透皮能力强,这对于新型透皮给药制剂的研究与开发具有重要意义,应对其给予关注。
Objective To study the preparation of osthole microemulsion and its transdermal ability. Methods The blank microemulsion formulation was designed by the solubility of osthole in different emulsifiers, co-emulsifiers and oil phase. The viscosity, particle size and conductivity of the prepared microemulsion were investigated. The transdermal rate of the bed microemulsion was measured, compared with osthol gel. Results The prepared osthole microprolactin had a viscosity of 8.05 mPas, a particle size of 57.9 nm and an electrical conductivity of 122 μscm-1. The results showed that the transdermal rate of osthol microemulsion was larger than that of osthol (P <0.05). Conclusion Osthole microemulsion transdermal ability, which for the new transdermal delivery of research and development of great significance, should pay attention to it.