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目的探讨布地奈德联合特布他林雾化吸入救治慢性阻塞性肺疾病(COPD)急性加重期的临床效果。方法 60例慢性阻塞性肺疾病急性发作期患者随机分为观察组和对照组,每组30例。两组患者均给予氧疗、给予抗生素等药物治疗,观察组患者同时给予布地奈德和特布特林联合雾化吸入治疗,对照组给予甲泼尼龙治疗。观察两组治疗前后的第1秒用力呼气容积及临床效果。结果观察组显效21例,有效7例,总有效率93.3%,对照组显效13例,有效8例,总有效率70.0%,观察组总有效率高于对照组,两组总有效率比较差异有统计学意义(P<0.05)。观察组治疗后的第1秒用力呼气容积高于对照组治疗后的第1秒用力呼气容积,差异有统计学意义(P<0.05)。结论布地奈德联合特布他林雾化吸入在COPD急性加重期患者的救治中效果显著,改善患者症状和肺功能作用显著,值得借鉴。
Objective To investigate the clinical efficacy of budesonide combined with terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods Sixty patients with acute exacerbation of chronic obstructive pulmonary disease were randomly divided into observation group and control group, 30 cases in each group. Both groups were given oxygen therapy, given antibiotics and other drugs, the observation group patients given budesonide and terbutaline combined with inhalation therapy, the control group was given methylprednisolone treatment. The first two seconds before and after treatment, forced expiratory volume and clinical effects were observed. Results The observation group was effective in 21 cases, effective in 7 cases, the total effective rate was 93.3%, the control group markedly effective in 13 cases, effective in 8 cases, the total effective rate was 70.0%, the total effective rate was higher in the observation group than in the control group, the total effective rate was significantly different There was statistical significance (P <0.05). The forced expiratory volume of the first second after the treatment in the observation group was higher than that in the control group at the first second, the difference was statistically significant (P <0.05). Conclusion Budesonide combined with terbutaline hydrochloride inhalation in patients with acute exacerbation of COPD in the treatment of significant effect to improve the patient’s symptoms and pulmonary function was significant and worth learning.