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目的探讨加味温胆汤对衰老的作用机理。方法采用Ｄ－半乳糖大鼠亚急性衰老模型，观察加味温胆汤抗衰老的作用。大鼠皮下注射Ｄ－半乳糖（４８ｍｇ／Ｋｇ）连续４０ｄ可使其脑组织ＭＡＯ活性升高（Ｐ＜０．０５），肝脏ＬＰＦ含量升高（Ｐ＜０．０５），而其血中ＧＳＨ－Ｐｘ活性降低（Ｐ＜０．０１）。在注射Ｄ－半乳糖同时灌胃加味温胆汤（φ（生药）＝１８．５ｇ／ｋｇ），可抑制模型动物肝ＬＰＦ含量的升高（Ｐ＜０．０５）和脑ＭＡＯ活性的升高（Ｐ＜０．０１），提高血中ＧＳＨ－Ｐｘ活性（Ｐ＜０．０１）。提示加味温胆汤具有抗衰老的作用，其作用机理可能与其抑制自由基反应，提高抗氧化酶活性及清除老化产物有关
Objective To explore the mechanism of Jiawei Wendan decoction on aging. Methods The subacute aging model of D-galactose rat was used to observe the anti-aging effect of Jiawei Wendan Decoction. Subcutaneous injection of D-galactose (48mg/Kg) for 40 days could increase MAO activity in brain tissue (P<0.05), increase LPF content in liver (P<0.05), and increase blood GSH levels. -Px activity decreased (P<0.01). Injecting D-galactose at the same time by gavage Jiawei Wendan Decoction (φ(crude drug)=18.5g/kg) can inhibit the increase of liver LPF (P<0.05) and the increase of brain MAO activity in model animals. (P<0.01), increased blood GSH-Px activity (P<0.01). Tips Warming soup has anti-aging effects. Its mechanism of action may be related to its inhibition of free radical reactions, increase of antioxidant enzyme activity and elimination of aging products