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目的:观察益元活血汤对恶性肿瘤患者的治疗作用和化疗期间对免疫功能的影响。方法:采用完全随机设计方法,将恶性肿瘤患者分为益元活血汤配合化疗组(治疗组)29例和单纯化疗组(对照组)27例,在化疗前及化疗4周期后,以外周血分别测定患者CD3,CD4,CD8,淋巴细胞非组蛋白(Ag-Nors),免疫球蛋白,同时观察本时期内患者的中医证候表现。对比两组之间的差异及治疗前后的差异。结果:恶性肿瘤患者化疗期间的免疫紊乱主要表现为细胞免疫下降,其中CD3,CD4,CD4/CD8,Ag-Nors水平均有所减低,免疫球蛋白变化不明显。通过益元活血汤治疗,能够延缓化疗导致的细胞免疫功能下降,但对体液免疫无明显影响。结论:益元活血汤对与化疗导致的细胞免疫紊乱有调节作用。
Objective: To observe the therapeutic effect of Yiyuan Huoxue Decoction on patients with malignant tumor and its effect on immune function during chemotherapy. Methods: A total of 29 patients with malignant tumor were randomly divided into Yiyuan Huoxue decoction combined with chemotherapy group (treatment group) and 27 patients with chemotherapy alone group (control group). Before chemotherapy and after 4 cycles of chemotherapy, peripheral blood Patients were measured CD3, CD4, CD8, lymphocyte non-histone (Ag-Nors), immunoglobulin, at the same time observed in this period of patients with TCM syndromes. Differences between the two groups were compared before and after treatment. Results: The immune disorders during the chemotherapy in patients with malignant tumors mainly showed decreased cellular immunity, in which the levels of CD3, CD4, CD4 / CD8 and Ag-Nors were all decreased while the immunoglobulin did not change obviously. The treatment of Yiyuan Huoxue Decoction can delay the decrease of cellular immune function caused by chemotherapy, but has no obvious effect on humoral immunity. Conclusion: Yiyuan Huoxue Decoction can regulate the cellular immune disorder caused by chemotherapy.