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用５％四氧嘧啶水溶液１７０ｍｇ／ｋｇ给ＳＤ大鼠皮下注射。２４小时后重复注射一次。实验组血糖值持续超过２８ｍｍｏｌ／Ｌ。两周末取颌下腺作电镜观察。实验组颗粒曲管上皮细胞呈现坏死变化。主要表现为核固缩和膜结构的破坏，多数线粒体肿胀，嵴变短、稀疏，甚至消失。与对照组相比，实验组空泡状线粒体的体积密度显著增加（Ｐ＜０．０１）。ＲＥＲ池扩张、脱颗粒，其体积密度较对照组有显著增加（Ｐ＜０．０５）。多数细胞分泌颗粒消失。它们的体积密度比对照组减少（Ｐ＜０．００１）。结果表明四氧嘧啶糖尿病大鼠颌下腺颗粒曲管上皮细胞呈显著的病理变化。
SD rats were injected subcutaneously with 170 mg / kg 5% aqueous solution of alloxan. 24 hours after repeated injections. The experimental group continued to exceed the blood glucose value 28mmol / L. Two weeks to take submandibular gland for electron microscopy. Experimental group of granular curved epithelial cells showed necrotic changes. Mainly manifested as nuclear pyknosis and destruction of membrane structure, the majority of mitochondria swelling, crest shorter, sparse, or even disappear. Compared with the control group, the bulk density of vacuolar mitochondria in the experimental group increased significantly (P <0.01). RER pool expansion, degranulation, the bulk density than the control group increased significantly (P <0.05). Most cells secreted particles disappear. Their bulk density decreased compared to the control group (P <0.001). The results showed that alloxan diabetic rat submandibular gland granular curved epithelial cells showed significant pathological changes.