长压定(minoxidil)是直接作用于动脉平滑肌的血管扩张药物.本文报道用长压定治疗严重或急进型高血压的近期和远期疗效及对肾功能的影响.病人和方法按照高血压和肾功能的程度将患者分三组。①组8例,男女各4例,用长压定治疗前肾小球滤过率正常或略有降低.其中包括肾血管性高血压3例,肾血管硬化2例,原发性高血压1例,慢性肾盂肾炎1例,慢性肾小球肾炎1例.②组9例,男8例,女1例,有轻至中度肾功能衰竭,肌 Minoxidil is a vasodilator that acts directly on arterial smooth muscle.We report the short-term and long-term effects of long-acting nifedipine in the treatment of severe or acute hypertension and its effects on renal function.Patients and methods according to hypertension and The extent of renal function will be divided into three groups of patients. ① group of 8 patients, 4 men and women, before and after treatment with long-term treatment of glomerular filtration rate was normal or slightly reduced, including 3 cases of renovascular hypertension, renal vascular sclerosis in 2 cases, essential hypertension 1 1 case of chronic pyelonephritis and 1 case of chronic glomerulonephritis.②The group of 9 cases, 8 males and 1 female, with mild to moderate renal failure, muscle