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目的探讨感染性疾病患者真菌的种类及耐药性特点,指导临床合理用药。方法对1000例疑有真菌感染标本进行培养鉴定及药物敏感实验。结果 1000株真菌标本中,以白色假丝酵母菌为主,占46.2%,其次为新型隐球菌,占24.0%。1000株真菌药敏实验分析抗真菌药物敏感性:两性霉素B最高,约占96.9%,5-氟胞嘧啶次之,占91.2%。抗真菌药耐药性氟康唑最高,占12.9%,伏立康唑次之,占3.4%,两性霉素B最少,占1.7%。结论真菌感染以白色假丝酵母菌为主,为临床感染性疾病诊疗提供病原学依据。
Objective To investigate the fungal species and drug resistance characteristics of patients with infectious diseases and to guide clinical rational drug use. Methods 1000 cases of suspected fungal infections were identified and drug susceptibility testing. Results Among the 1000 strains of fungi, Candida albicans was the most common type, accounting for 46.2%, followed by Cryptococcus neoformans, accounting for 24.0%. Antifungal susceptibility of 1000 strains of fungi was analyzed by sensitivity test. Amphotericin B was the highest, accounting for 96.9%, followed by 5-fluorocytosine, accounting for 91.2%. Antifungal resistance fluconazole highest, accounting for 12.9%, voriconazole second, accounting for 3.4%, amphotericin B least, accounting for 1.7%. Conclusions Fungal infections are mainly Candida albicans and provide etiological evidence for clinical diagnosis and treatment of infectious diseases.