目前公认肝星状细胞是肝纤维化发生发展的关键细胞,只有活化的肝星状细胞才能出现增殖和凋亡,肝星状细胞只有活化后才能参与胶原的合成、降解和细胞外基质(ECM)的沉积。有研究表明肝纤维过程中,肝形状细胞活化增加,且环氧合酶-2与瘦素的分泌也明显增加,并对肝纤维化的发展起着重要影响。 It is recognized that hepatic stellate cells are the key cells in the development of hepatic fibrosis. Only activated hepatic stellate cells can proliferate and apoptosis. Only hepatic stellate cells can participate in collagen synthesis, degradation and extracellular matrix (ECM) ) Deposition. Studies have shown that during liver fibrosis, activation of liver-shaped cells increased, and secretion of cyclooxygenase-2 and leptin also significantly increased, and the development of hepatic fibrosis plays an important role.