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目的探讨自拟中药汤剂与西医结合治疗复发性口腔溃疡的疗效。方法分析2010年1-12月收治的复发性口腔溃疡(recurrent oralulcer,ROU)患者114例,按随机数字表法分为对照组和观察组。对照组55例,给予西医常规治疗方法,即口服维生素B、C,应用金霉素药膜,口服强的松片。观察组59例,在对照组的基础上加用自拟汤剂“溃疡灵”。比较两组患者2年来临床近期疗效、溃疡时间、疼痛指数及复发率。结果 (1)两组临床总有效率观察组为91.5%(54/59),对照组为78.2%(43/55),差异具有统计学意义(P<0.05)。(2)两组患者溃疡时间(4.7vs7.1)、疼痛指数(17vs.36)、复发率(3.4%vs.16.4%)方面观察组均显著低于对照组,差异有统计学意义(P<0.05)。结论中药汤剂与西医结合治疗复发性口腔溃疡,可以提高临床疗效、缩短病程、减轻疼痛及复发率,值得临床推广。
Objective To explore the curative effect of self-made traditional Chinese medicine decoction combined with western medicine in the treatment of recurrent oral ulcer. Methods 114 cases of recurrent oral ulcer (ROU) admitted from January to December in 2010 were divided into control group and observation group according to random number table. The control group of 55 patients were given conventional Western medicine treatment, that is, oral vitamin B, C, the application of aureomycin membrane, oral prednisone tablets. Observation group of 59 cases, on the basis of the control group with self-made decoction “ulcer spirit ”. The two groups of patients in recent clinical efficacy, ulcer time, pain index and recurrence rate. Results (1) The total effective rate in the observation group was 91.5% (54/59) in the observation group and 78.2% (43/55) in the control group, the difference was statistically significant (P <0.05). (2) The ulcer time (4.7 vs 7.1), the pain index (17 vs. 36) and the recurrence rate (3.4% vs.16.4%) in the two groups were significantly lower than those in the control group (P <0.05). Conclusion Chinese medicine decoction combined with Western medicine treatment of recurrent oral ulcer can improve clinical efficacy, shorten the course of the disease, reduce pain and recurrence rate, worthy of clinical promotion.