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目的:对紫苏油乳剂进行皮肤急性毒性试验、皮肤刺激性试验及皮肤过敏性试验,以了解其安全性。方法:将紫苏油乳剂用于家兔背部完整或破损去毛区皮肤,观察其产生急性毒性和皮肤刺激性情况;采用致敏与激发接触紫苏油,观察豚鼠过敏情况。结果:紫苏油乳剂未产生明显皮肤刺激性;反复致敏后使用,也无皮肤与全身过敏反应。结论:紫苏油乳剂皮肤用药是安全的。
OBJECTIVE: To evaluate the skin acute toxicity test, skin irritation test, and skin allergy test for perilla oil emulsions. Methods: Perilla oil emulsion was applied to the intact or damaged skin of the rabbit’s back to observe the acute toxicity and skin irritation. The sensitized and stimulated contact with perilla oil was used to observe the guinea pig allergy. Results: Perilla oil emulsion did not produce significant skin irritation; after repeated sensitization, there was no skin and systemic allergic reaction. Conclusion: Perilla oil emulsions are safe for use on the skin.