真性红细胞增多症的临床特征及血栓栓塞并发症危险因素分析

来源 :临床血液学杂志 | 被引量 : 0次 | 上传用户:darkblueangel
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目的:总结真性红细胞增多症(PV)患者的临床特点、实验室检查结果,分析PV患者血栓栓塞并发症的危险因素,为筛选高危人群、防治并发症提供依据.方法:选取确诊的107例PV患者的临床资料进行回顾性分析总结.结果:①JAK2/V617F突变阳性的PV患者,年龄、血小板计数明显高于阴性者(P<0.05).②107例患者中,PT延长41例(38.32%),APTT延长70例(65.42%),TT延长40例(37.38%),PTA降低74例(69.16%),INR升高38例(35.51%),FIB降低27例(25.23%).③共88例患者检测了乳酸脱氢酶(LDH),均值为355.66 U/L,明显大于正常高限(240 U/L),共89例患者检测了空腹血糖,均值为4.44 mmol/L,其中30例(33.71%)空腹血糖低于正常低限(3.8 mmol/L),12例可诊断为低血糖症(空腹血糖450×109/L、无脾肿大的患者,更易并发血栓性疾病.“,”Objective: To summarize clinical features and laboratory test results of patients with polycythemia vera (PV),and analyze risk factors of thromboembolic complications in PV patients, in order to provide basis for screening high-risk groups and prevention of complications. Method: Clinical data of 107 patients diagnosed with PV were retrospectively analyzed. Result:①According to whether the existence of JAK2/V617F mutation,PV patients could be divided into two groups, the age, platelet count of positive group was obviously higher than those of negative group (P<0.05);②Of all the 107 patients,PT prolonged in 41 cases (38.32%),APTT prolonged in 70 cases (65.42%),TT prolonged in 40 cases (37.38%), the PTA decreased in 74 cases (69.16%), INR increased in 38 cases (35.51 %),FIB decreased in 27 cases (25.23%);③A total of 88 cases received the test of LDH,averaged 355.66 U/L,it was significantly higher than the normal range (240 U/L). Eighty-nine cases tested the fasting glucose, averaged 4.44 mmol/L,and 30 cases belowed the normal lower limit (3.8 mmol/L,33.71%),12 cases diagnosed as hypoglycemia (fasting glucose 450 X 109/L,patients without splenomegaly are more likely to have thrombotic disease.
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