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目的：探讨多系统萎缩（ＭＳＡ）的临床特点，以及磁共振成像（ＭＲＩ）和脑干听觉诱发电位（ＢＡＥＰ）对不同类型ＭＳＡ的诊断价值。方法：对５０例ＭＳＡ的临床资料、ＭＲＩ和ＢＡＥＰ进行回顾性分析。结累：５０例ＭＳＡ中，散发型橄榄桥脑小脑萎缩（ＳＯＰＣＡ）２５例，占５０．０％，临床上以小脑型共济失调为主要表现，ＢＡＥＰ最敏感，ＭＲＩ次之；纹状体黑质变性（ＳＮＤ）１５例，占３０％，以肌张力增高为主，ＭＲＩ最敏感，ＢＡＥＰ次之。Ｓｈｙ—ｄｒａｇｅｒ综合征（ＳＤＳ）１０例，占２０％，以直立性低血压和头晕为主，ＢＡＥＰ最敏感。而且将ＳＮＤ与原发性帕金森综合征（ＩＰＤ）的ＢＡＥＰ相比，前者的敏感性明显升高，差别有显著性。结抡：ＭＳＡ分型不同临床表现各有侧重，ＭＲＩ及 ＢＡＥＰ在 ＭＳＡ诊断和鉴别诊断中有极重要价值。
Objective: To investigate the clinical features of multiple system atrophy (MSA) and the diagnostic value of magnetic resonance imaging (MRI) and brainstem auditory evoked potential (BAEP) in different types of MSA. Methods: The clinical data of 50 cases of MSA, MRI and BAEP were analyzed retrospectively. In 50 MSA cases, sporadic olivopontocerebellar atrophy (SOPCA) occurred in 25 cases (50.0%). Cerebellar ataxia was the main manifestation in clinical practice. BAEP was the most sensitive and MRI was the second. 15 cases of substantia nigra degeneration (SND), accounting for 30%, with the main muscle tone increased, MRI the most sensitive, followed by BAEP. Shy-drager syndrome (SDS) 10 cases, accounting for 20%, mainly orthostatic hypotension and dizziness, BAEP the most sensitive. And SND and primary Parkinson’s disease (IPD) BAEP compared to the former significantly increased the sensitivity, the difference was significant. Results: MSA classification of different clinical manifestations have different emphases, MRI and BAEP in MSA diagnosis and differential diagnosis of great value.