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目的探讨心脑血管疾病高危患者超敏C反应蛋白(CRP)的变化情况,以及其对高危患者短期内发生心脑血管事件的预测价值。方法选取心脑血管疾病高危患者76例和对照组健康老年人53人,均检测并比较两组血清超敏CRP水平;随访记录高危患者1年内心脑血管事件发生情况。结果高危患者血清超敏CRP值高于对照组,高危患者中超敏CRP异常组心脑血管事件的发生率高于CRP正常组,差异均有统计学意义(分别P<0.01和<0.05);多因素Logistic回归分析超敏CRP是高危患者1年内发生心脑血管事件独立危险因素。结论监测心脑血管疾病高危患者超敏CRP水平有一定临床意义,超敏CRP异常升高预示短期内发生心脑血管事件的可能性增加。
Objective To investigate the changes of high-sensitivity C-reactive protein (CRP) in high-risk patients with cardiovascular and cerebrovascular diseases and their predictive value in short-term cardiovascular and cerebrovascular events in high-risk patients. Methods 76 high-risk patients with cardiovascular and cerebrovascular diseases and 53 healthy elderly controls were enrolled in this study. The levels of serum CRP in both groups were detected and compared. The incidence of cardiovascular and cerebrovascular events within 1 year of high-risk patients were followed up. Results Serum high CRP values were higher in high-risk patients than those in control group. The incidence of cardiovascular and cerebrovascular events in high-risk CRP abnormal patients was significantly higher than that in normal CRP patients (P <0.01 and <0.05, respectively) Factors Logistic regression analysis of hypersensitive CRP is an independent risk factor for cardiovascular events within 1 year of high-risk patients. Conclusion It is of clinical significance to monitor the level of CRP in high-risk patients with cardiovascular and cerebrovascular diseases. The abnormal increase of hypersensitive CRP is predicted to increase the possibility of cardiovascular and cerebrovascular events in short term.