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目的 探讨新生儿机械通气时发生低碳酸血症的病因、危害性及其防治措施。方法选择我院1994年1月-2003年12月10年间,在NICU住院新生儿应用气管插管呼吸机治疗持续时间≥12h者共246例,以发生低碳酸血症的病例为研究对象,未发生者作为对照组,进行临床对照分析。结果低碳酸血症的发病率为14．2％,以早产儿多见,平均发生时间为(31．6±26．9)h,原发病以呼吸窘迫综合征最常见(22．6％),发生低碳酸血症者死亡率(32．9％)和颅内出血发生率(20％)明显高于对照组(P<0．01)。结论新生儿应慎重选择机械通气指征,维持PaO2在正常范围,避免PaCO2<35mmHg,以减少呼吸机合并症,在降低新生儿病死率同时,改善新生儿的预后。
Objective To investigate the etiology and harm of hypocapnia in neonatal mechanical ventilation and its preventive measures. Methods Select our hospital from January 1994 to December 2003 10 years, NICU hospitalized neonatal endotracheal intubation ventilator treatment duration of ≥ 12h, a total of 246 cases of hypocapnia in the study as the research object, The occurrence as a control group, clinical control analysis. Results The incidence of hypocapnia was 14.2%, prevalent in preterm children, the average occurrence time was (31.6 ± 26.9) h, the primary disease with respiratory distress syndrome was the most common (22.6% ), The incidence of hypocapnia (32.9%) and the incidence of intracranial hemorrhage (20%) were significantly higher than those of the control group (P <0.01). Conclusion Newborns should be carefully chosen mechanical ventilation indications, to maintain PaO2 in the normal range, to avoid PaCO2 <35mmHg, in order to reduce ventilator complications, reduce neonatal mortality while improving the prognosis of newborns.