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目的探讨抗双链DNA抗体(抗dsDNA)、抗脂蛋白酶抗体(抗LPL)和抗C1q抗体(抗C1q)单项检测和联合检测在狼疮性肾炎(LN)诊断中的价值。方法将77例SLE患者分为A组(LN组,41例)和B组(非LN组,36例),比较抗dsDNA、抗LPL和抗C1q单项及联合检测与LN的关系。结果在A组患者中抗dsDNA、抗LPL、抗C1q单项和联合检测阳性率均显著高于B组(P<0.05)。3种自身抗体联合检测与单项检测比较,敏感性有所降低,但特异性明显提高。抗LPL、抗Clq与抗dsDNA诊断一致性均较好(KLPL=0.447,P<0.001;KC1q=0.436,P<0.001)。结论抗dsDNA、抗LPL和抗C1q单项和多项联合检测能很好有助于LN的早期诊断,抗LPL和抗C1q在一定程度上可弥补抗dsDNA对LN诊断的不足。
Objective To investigate the value of anti-dsDNA antibody, anti-lipoprotein antibody (anti-LPL) and anti-C1q antibody (anti-C1q) single detection and combined detection in the diagnosis of lupus nephritis (LN). Methods A total of 77 patients with SLE were divided into group A (n = 41) and group B (n = 36). The relationship between anti-dsDNA, anti-LPL and anti- Results The positive rates of anti-dsDNA, anti-LPL and anti-C1q single and combined tests in group A were significantly higher than those in group B (P <0.05). The combination of three kinds of autoantibodies with single test, the sensitivity decreased, but the specificity was significantly improved. Anti-LPL, anti-Clq and anti-dsDNA diagnostic consistency are good (KLPL = 0.447, P <0.001; KC1q = 0.436, P <0.001). Conclusion The combination of single and multiple anti-dsDNA, anti-LPL and anti-C1q can be very helpful for the early diagnosis of LN. Anti-LPL and anti-C1q can make up for the deficiency of anti-dsDNA to LN diagnosis to a certain extent.