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本文报告用霉康唑治愈一例由交链孢霉引起的皮肤肉芽肿.患者为男性40岁.初发损害为在10年前一次割麦的劳动中,右腰皮肤受到小创伤.尔后局部出现红色丘疹,逐渐向周围发展,继而中央结痂,变成纤维化结节,在一年中发展到了3cm直径.用0.1%倍他米松霜治疗无效,且出现新的损害和浅表溃疡.检查:一般情况良好,仅在右腰前有10×15cm的疤痕样硬结损害,腰弯曲受限.血液学及生化试验正常,胸、腰X线摄片正常.损害区表浅刮片培养有交链孢霉及链球菌生长.损害区活检,可见表皮增厚,伴有少数脓肿形成.真皮上部有多形核白细胞、组织细胞和巨细胞浸润.有些巨细胞浆内有PAS染色阳性的圆形结构,在浸润区还有长的菌丝.后用3mm钻孔器进行活检,所得5次不同的
This article reports the treatment of a case of cutaneous granuloma caused by Alternaria alternata with meconazole, a 40-year-old man with a first-onset lesion with a minor trauma to his right loin skin during a wheat cut 10 years ago. The red papules gradually developed around the area, followed by a central crusting that turned into fibrotic nodules, which developed to 3 cm in diameter over a year. Treatment with 0.1% betamethasone cream was ineffective with new lesions and superficial ulcers. : Generally good, only 10 × 15cm in the right lumbar scars before the sclerosis, lumbar curve is limited to hematology and biochemical tests normal, chest, waist X-ray normal. Streptomyces and streptococcus growth damage zone biopsy, showing epidermal thickening, accompanied by a small number of abscess formation.The upper dermis with polymorphonuclear leukocytes, tissue cells and giant cell infiltration.Some giant cytoplasm of PAS staining positive round Structure, there is still a long mycelium in the infiltration zone.After 3mm biopsy biopsy, the resulting 5 different