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目的 :探讨不同中药注射剂对 2型糖尿病并发急性脑梗死患者应激激素和免疫细胞因子的影响及其临床意义。方法 :用放射免疫分析法 (RIA)对使用蛇毒制剂 (降纤酶 )、刺五加及金钠多 (银杏叶提取物 )注射液 3组病例 (各为 32、2 0、12例 )进行治疗前后促肾上腺皮质释放激素 (CRH)、促肾上腺皮质激素(ACTH)、皮质醇 (CS)、肿瘤细胞坏死因子 (TNFα)与白细胞介素 6(IL 6)含量检测 ,分析其变化特点 ,并与健康人组 ( 30名 )作比较。结果 :( 1) 3组患者入院治疗前应激激素与免疫细胞因子水平均显著高于健康人组(P <0 0 1) ;( 2 )治疗后 3组患者可随其含量的下降而显见改善 ,且以降纤酶组最为突出 (P <0 0 1)。结论 :3种中药注射剂对本病的作用机制与应激激素和免疫细胞因子水平关系密切 ,监测其变化对评价其疗效 ,阐明中药药理有重要临床价值
Objective: To investigate the effect and clinical significance of different traditional Chinese medicine injections on stress hormones and immune cytokines in patients with type 2 diabetes complicated with acute cerebral infarction. METHODS: Radioimmunoassay (RIA) was performed on 3 groups of patients (32, 20, and 12 each) using snake venom preparation (defibrinated enzyme), Acanthopanax senticosus, and Jin Naido (Ginkgo biloba extract) injection. Before and after treatment, adrenocortical release hormone (CRH), adrenocorticotropic hormone (ACTH), cortisol (CS), tumor necrosis factor (TNFα) and interleukin 6 (IL 6) levels were detected, and their changes were analyzed. Compare with healthy group (30). Results: (1) The levels of stress hormones and immune cytokines before admission in the three groups were significantly higher than those in the healthy group (P < 0.01); (2) After treatment, the 3 groups of patients could be seen with the decrease in their levels. Improvement was observed in the defibrase group (P < 0 01). Conclusion: The mechanism of action of the three traditional Chinese medicine injections on the disease is closely related to the level of stress hormones and immune cytokines. Monitoring the changes of the traditional Chinese medicine injections to evaluate the efficacy of the drugs and clarifying the pharmacology of traditional Chinese medicine have important clinical value.