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目的 观察肉毒杆菌毒素Ａ（ＢＴＡ） 治疗先天性眼球震颤（ＣＮ） 的效果，并进一步探讨其应用规律。 方法 对２２ 例先天眼震患者，用兰州生物制品所生产的ＢＴＡ，以眼震图（ＥＮＧ） 检查注射前与注射后１ 周，１ ，３ ，６ 月的近、远距离眼震情况，各组进行统计学处理，并比较统计学差异。 结果 注药后１ 周与注药前相比近距离原眼位眼震振幅降低有明显统计学差异（ Ｐ＜ ０ ．０５） ；注药后１ 月与注药前相比，除近距离原眼位震频降低无明显统计学差异（ Ｐ＞ ０ ．０５） 外，其它远、近距离原眼位的各眼震参数降低均有明显统计学差异（ Ｐ＜ ０ ．０５） ；注药后３ ，６ 月与注药前相比近、远距离原眼位振幅降低有明显统计学差异（ Ｐ＜ ０ ．０５） ；最小震强位置注药后１ 周，１ ，３ ，６ 月与注药前相比虽无显著差异，但从频数分布图中可见最小震强出现的位置有向原眼位集中的趋势。 结论 该方法治疗先天性眼球震颤可使近、远距离原眼位眼震有所减轻，代偿头位有所改善。注药后１ 月疗效最显著，注药后３ 月疗效开始回退，但可重复注药。该方法治疗先天性眼球震颤有明显效果，可成为今后临床治疗先天性眼球震颤的新方法
Objective To observe the effect of botulinum toxin A (BTA) in the treatment of congenital nystagmus (CN) and to explore its application rules. Methods Twenty-two patients with congenital nystagmus were examined with the nystagmus (ENG) with BTA produced by Lanzhou Biological Products before and after 1 week, 1, 3, 6 months after injection. Group for statistical analysis, and compare statistical differences. Results The amplitude of nystagmus was significantly lower at 1 week after injection compared with that before injection (P <0 .05). Compared with that before injection, (P> 0.05), the other nystagmus parameters of far and near original ocular position had significant statistical difference (P <0 .05); after injection The amplitude of long-range original ocular anomaly decreased significantly in 3 and 6 months after injection compared with that before injection (P <0 .05) Although there was no significant difference in the pre-drug, the trend of concentration of the original eye position was observed in the frequency distribution. Conclusion The method of treatment of congenital nystagmus can make near and long-distance original ocular anorexia slightly reduced, compensatory head position improved. After injection, the most obvious effect was in January. After 3 months of injection, the curative effect began to retreat, but the injection could be repeated. This method has obvious effect on the treatment of congenital nystagmus and may become a new method for clinical treatment of congenital nystagmus