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以碳酸二甲酯为甲基化试剂,同时探索了在此合成工艺下的最佳反应温度、溶剂和缚酸剂,实现了盐酸达泊西汀的绿色合成,收率达到85.34%。
Dimethyl carbonate was used as methylation reagent. The best reaction temperature, solvent and acid-binding agent were explored in this synthesis process. The green synthesis of dapoxetine hydrochloride was achieved with a yield of 85.34%.