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目的 :探讨促炎细胞因子在慢性鼻窦炎发病机制中的作用。方法 :应用免疫组化SABC法对两型慢性鼻窦炎上颌窦粘膜内白细胞介素 1, 8(IL 1,IL 8)和肿瘤坏死因子 (TNF)进行检测。结果 :在慢性单纯性鼻窦炎Ⅰ型组中IL 1、IL 8和TNF阳性细胞数明显高于对照组 (P <0 .0 1) ,而Ⅱ型组中IL 8和TNF阳性细胞数明显高于对照组 (P <0 .0 1) ;Ⅰ型组IL 1明显高于Ⅱ型组 (P <0 .0 1) ;另两类细胞因子在两组间差异无显著性意义。结论 :促炎细胞因子在慢性鼻窦炎发病中起一定作用 ,但两型鼻窦炎起作用的细胞因子并不相同 ,通过对不同细胞因子类型的研究可以进一步了解慢性鼻窦炎不同类型发病机制的差异
Objective: To investigate the role of proinflammatory cytokines in the pathogenesis of chronic sinusitis. Methods: The interleukin 1, 8 (IL 1, IL 8) and tumor necrosis factor (TNF) in mucosa of maxillary sinus of patients with chronic sinusitis were detected by immunohistochemical SABC method. Results: The number of positive cells of IL-1, IL-8 and TNF in chronic simple sinusitis type Ⅰ group was significantly higher than that in control group (P <0.01), but the number of IL-8 and TNF-positive cells in type Ⅱ group was significantly higher In the control group (P <0.01), the level of IL-1 in type I group was significantly higher than that in type II group (P <0.01). There were no significant differences in the other two types of cytokines between the two groups. CONCLUSIONS: Proinflammatory cytokines play a role in the pathogenesis of chronic sinusitis, but cytokines that play a role in both types of sinusitis are not the same. Differences in different types of pathogenesis of chronic sinusitis can be further explored by studying different cytokine types