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目的探讨术后3疗程化疗后血清CA_(125)不同的界值对卵巢上皮癌预后评估的意义。方法对我院妇泌科自1998年1月1日至2002年12月30日期间收治的94例术后行6～8疗程化疗的卵巢上皮癌患者,在化疗3个疗程后进行血清CA_(125)测定。血清CA_(125)分别以正常值(35U/ml)、正常值的2倍(70U/ml)和3倍(105U/ml)为界值,以累积生存率和平均生存期为参数,绘制Kaplan-Meier生存曲线,log-rank test法作预后分析。结果术后3疗程化疗后血清CA_(125)≤35U/ml和CA_(125)>35U/ml患者累积生存率相比较,差异无统计学意义(P=0.0693);术后3疗程化疗后CA_(125)≤70U/ml的患者的累积生存率与CA_(125)>70U/ml组比较,差异无统计学意义(P=0.1074);术后3疗程化疗后CA_(125)≤105U/ml的患者累积生存率较CA_(125)>105U/ml的患者高(P=0.0171)。结论术后化疗3疗程后血清CA_(125)以105U/ml为界值对卵巢上皮癌的预后评定有一定的临床价值,检测该指标对上皮性卵巢癌的预后有一定的指导作用。
Objective To investigate the significance of the different cutoffs of serum CA 125 after 3 courses of chemotherapy on the prognosis of ovarian epithelial carcinoma. Methods A total of 94 patients with ovarian epithelial carcinoma treated with chemotherapy of 6 to 8 courses were treated in our hospital from January 1, 1998 to December 30, 2002. After three courses of chemotherapy, serum CA 125 ). Serum CA 125 was used as a cutoff to calculate the cumulative survival rate and mean survival time at normal (35U / ml), 2 times normal (70U / ml) and 3 times (105U / ml) -Meier survival curve, log-rank test for prognostic analysis. Results There was no significant difference in cumulative survival rate between three groups after three courses of chemotherapy (P> 0.05). The cumulative survival rates of patients with CA 125 (125U) ≤ 35U / ml and CA125 125U / The cumulative survival rate of patients with (125) ≤70U / ml was not significantly different from that of CA125125U / ml group (P = 0.1074) Of patients had higher cumulative survival rates than those with CA 125 (125)> 105 U / ml (P = 0.0171). Conclusions There is a certain clinical value for the prognosis evaluation of epithelial ovarian cancer after serum CA 125 was treated with 105 U / ml after 3 cycles of chemotherapy. The detection of this index may play a guiding role in the prognosis of epithelial ovarian cancer.