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目的:观察阿卡波糖合用荷丹片降低餐后血糖、改善胰岛素敏感性的作用。方法:选择106例单纯餐后高血糖的老年患者,分为单用阿卡波糖组(对照组)53例,和荷丹片合用阿卡波糖组(观察组)53例,治疗2个月后分别观察两组的餐后血糖(2 h PG)、血脂、体重指数、以及胰岛素抵抗指数和不良反应等指标的变化。结果:观察组2 h PG、BM I、胆固醇(CH)和低密度脂蛋白(LDL-C)、甘油三脂(TG)较对照组改善明显(P<0.05)。胰岛素抵指数两组均有明显改善(P<0.05),且观察组与对照组比较差异有显著性(P<0.01)。观察组不良反应明显比对照组减少。结论:阿卡波糖与荷丹片合用,不仅可改善餐后高血糖状态,而且明显增强胰岛素敏感性,对血脂、体重指数等也有明显的改善作用,两药合用后,阿卡波糖的不良反应明显减少。
Objective: To observe the effect of acarbose combined with holtein to reduce postprandial blood glucose and improve insulin sensitivity. Methods: A total of 106 elderly patients with simple postprandial hyperglycemia were selected and divided into acarbose group (control group) alone and 53 cases with acarbose group (observation group) The changes of postprandial blood glucose (2 h PG), lipids, body mass index, insulin resistance index and adverse reactions were observed in two groups respectively. Results: The levels of PG, BM I, CH and LDL-C and triglyceride (TG) in the observation group improved significantly (P <0.05) compared with the control group. Insulin resistance index was significantly improved in both groups (P <0.05), and the difference between the observation group and the control group was significant (P <0.01). Adverse reactions in the observation group were significantly lower than those in the control group. Conclusion: Combination of acarbose and holtein can not only improve the state of postprandial hyperglycemia, but also significantly enhance insulin sensitivity, and also have a significant improvement on blood lipids and body mass index. After the combination of acarbose and acarbose Adverse reactions decreased significantly.