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一般认为乳腺癌的预后直接与诊断时间和早期治疗有关,因而研究的主要方向为早期发现。有计划地对乳腺肿物进行筛查使早期发现乳腺癌的机会增加.本文综述一种特殊的非浸润性乳腺恶性疾患——小叶原位癌(LCIS)的独特生物学现象及其流行病学、疾病进程、诊断及治疗中的一系列问题。一、流行病学及危险因素 1.群体病率由于男性乳腺一般不含小叶成分,故LCIS似仅发生在女性。已报导的诊断时间为44～47岁。发病年龄为20～83岁,比浸润性乳腺癌要早5～15年,90%的LCIS妇女为绝经前期。日本妇女发病率较美国要低,可能与环境因素,如饮食、辐射或毒性化学物质的作用有关。此外,LCIS好发于左乳,多在乳房上限内。
Generally believed that the prognosis of breast cancer directly related to the diagnosis and early treatment, so the main direction of the study for the early detection. The planned screening of breast masses increases the chance of early detection of breast cancer.This article reviews the unique biological phenomenon and epidemiology of a special non-invasive breast malignancy, lobular carcinoma in situ (LCIS) , Disease progression, diagnosis and treatment of a series of problems. First, the epidemiology and risk factors 1. Population prevalence As the male breast generally does not contain leaflet components, so LCIS may occur only in women. Has been reported for diagnosis of 44 to 47 years old. The age of onset is 20 to 83 years old, 5 to 15 years earlier than invasive breast cancer and 90% of LCIS women are premenopausal. The incidence of Japanese women is lower than in the United States, and may be related to the role of environmental factors such as diet, radiation or toxic chemicals. In addition, LCIS occurs in the left breast, mostly in the upper breast.