The interaction zone between southern Tianshan and northern Tarim is located at the northeast side of Pamir. It is a region with high seismicity. We constructed a seismotectonic model for the west part of this zone from geological profiles, deep crust seismic detection and earthquake focal mechanisms data. Based on the synthesized geological features, deep crust structure, and earthquake focal mechanisms, we think that the main regional tectonic feature is that the Tianshan tecto-lithostratigraphic unit overthrusts on the Tarim block. The Tianshan tectonic system includes the Maidan fault and thrust sheets in front of the fault; The Tarim tectonic system includes the underground northern Tarim margin fault, conjugate faults in basement and overthrust fault in shallow. The northern Tarim margin fault is a high angle fault deep in the Tarim crust, adjusting different trending deformation between Tianshan and Tarim. It is a major active fault that can generate large earthquakes. The other faults, such as the Tianshan overthrust system and the Tarim basement faults in this area may generate moderately strong earthquakes with different styles. The interaction zone between southern Tianshan and northern Tarim is located at the northeast side of Pamir. It is a region with high seismicity. We constructed a seismotectonic model for the west part of this zone from geological profiles, deep crust seismic detection and earthquake focal mechanisms data. Based on the synthesized geological features, deep crust structure, and earthquake focal mechanisms, we think that the main regional tectonic feature that the Tianshan tecto-lithostratigraphic unit overthrusts on the Tarim block. The Tianshan tectonic system includes the Maidan fault and thrust sheets in front of the fault; The Tarim tectonic system includes the underground northern Tarim margin fault, conjugate faults in basement and overthrust fault in shallow. The northern Tarim margin fault is a high angle fault deep in the Tarim crust, adjusting different trending deformation between Tianshan and Tarim. It is a major active fault that can generate large earthquakes. The other faults, such as the the Tianshan overthrust system and the Tarim basement faults in this area may generate moderately strong earthquakes with different styles.